| Office of the Acting Chair Peter A. Feldman | Contact Form | | |
| Office of Commissioner Mary T. Boyle | Contact Form | | |
| Office of Commissioner Richard Trumka Jr. | Contact Form | | |
| Office of Commissioner Alex Hoehn-Saric | Contact Form | | |
| Office of Commissioner Douglas Dziak | Contact Form | | |
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| Office of Legislative Affairs | | | |
| Director - John Mitchell | Contact Form | (301) 504 7853 | |
| Deputy Director - Andrew Ginsburg | Contact Form | (301) 504 7853 | (978) 967 2797 |
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| Office of the Inspector General | | | |
| Inspector General - Christopher Dentel | Contact Form | (301) 504 7905 | (301) 504 7004 |
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| Office of Equal Employment Opportunity and Employee Engagement | | | |
| Director - Brittany Woolfolk | Contact Form | (301) 504 7596 | (301) 504 0107 |
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| Office of Communications | | | |
| Director - Pamela Rucker Springs | Contact Form | (301) 504 7882 | |
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| Office of the General Counsel | | | |
| General Counsel - Matthew Campbell | Contact Form | (301) 504-7402 | |
| Office of the Secretary - Alberta Mills | Contact Form | (301) 504 7479 | (301) 504 0127 |
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| Office of the Executive Director | | | |
| Executive Director - Brien Lorenze | Contact Form | (301) 504 7126 | |
| Deputy Executive Director: Safety Operations – DeWane Ray | Contact Form | (301) 504 7126 | |
| Deputy Executive Director: Operations Support – Annette Evans | Contact Form | (301) 504 7126 | |
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| Office of Compliance and Field Operations | | | |
| Acting Director – Jen Sultan | Contact Form | (301) 504-7520 | |
| Deputy Assistant Executive Director - Jen Sultan | Contact Form | | |
| Director, Division of Field Investigations - Beverly Kohen | Contact Form | (240) 429 4936 | (866) 686 7937 |
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| Office of Risk Reduction | | | |
| Assistant Executive Director – Duane Boniface | Contact Form | (301) 504 7671 | (301) 504 0038 |
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| Directorate for Epidemiology | | | |
| Associate Executive Director - Steve Hanway | Contact Form | (301) 504 7256 | |
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| Directorate for Health Sciences | | | |
| Associate Executive Director - Mary Kelleher | Contact Form | (301) 987 2561 | |
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| Directorate for Engineering Sciences | | | |
| Associate Executive Director - Mark Kumagai | Contact Form | (301) 987 2234 | |
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| Directorate for Laboratory Sciences | | | |
| Associate Executive Director - Andrew Stadnik | Contact Form | (301) 987 2037 | (978) 367 1824 |
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| Directorate for Economic Analysis | | | |
| Associate Executive Director – Alex Moscoso | Contact Form | (301) 504 7782 | |
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| Office of Import Surveillance | | | |
| Director - James Joholske | Contact Form | (301) 504 7527 | |
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| Office of International Programs | | | |
| Acting Director - DeWane Ray | Contact Form | (301) 504 7126 | |
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| Office of Facilities Services | | | |
| Director - Cary Windsor | Contact Form | (301) 504-7203 | |
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| Office of Financial Management, Planning and Evaluation | | | |
| Acting Chief Financial Officer - Casey Waithe | Contact Form | (301) 504 7802 | |
| Deputy Chief Financial Officer - Casey Waithe | | (301) 504 7802 | (978) 367 9434 |
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| Office of Human Resource Management | | | |
| Acting EXHR Director - Ellen Lee | Contact Form | (301) 504-7677 | (301) 504 0432 |
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| Office of Information Technology | | | |
| Assistant Executive Director and CIO - Bryan Burnett | Contact Form | (301) 504 7654 | |
