Section 108 of the Consumer Product Safety Improvement Act of 2008 (CPSIA) requires the U.S. Consumer Product Safety Commission to convene a Chronic Hazard Advisory Panel (CHAP) to study the effects on children’s health of all phthalates and phthalate alternatives as used in children’s toys and child care articles. The CHAP shall make recommendations to the Commission regarding any phthalates (or combinations of phthalates) in addition to those identified in section 108 of the CPSIA or phthalate alternatives that the panel determines should be declared banned hazardous substances. This page lists several documents that have been received by the CHAP. Presentations and reports submitted to a CHAP meeting are available at the page dedicated to that meeting.

Reports and Other Related Documents not Presented at a CHAP Meeting

CPSC Staff Documents
Toxicity Reviews of 1,2-benzenedicarboxylic acid, di-2-propenyl ester (diallyl phthalate), bis(2-methoxyethyl) phthalate (DMEP), and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB), February 2011 [PDF]

Documents Received from Non-CPSC Sources

These documents were not prepared by the Commission or Commission staff and are not official documents of the CPSC, have not been reviewed by, and may not necessarily reflect the views of, the Commission.

Letter for OMB from Several Organizations Regarding the Chronic Hazard Advisory Panel (CHAP) on Phthalates, April 23, 2013

Letter to OMB from the American Chemistry Council about the CHAP report about phthalates, April 8, 2013

Chairman's response to Breast Care Fund, regarding the operations of the independent Chronic Hazard Advisory Panel on Phthalates and Phthalate Substitutes, March 22, 2013

Chairman's response to American Chemistry Council, regarding the operations of the independent Chronic Hazard Advisory Panel on Phthalates, March 22, 2013

Letter [PDF] from Cal Dooley, American Chemistry Council, regarding the operations of the independent Chronic Hazard Advisory Panel on Phthalates, March 15, 2013

Public health organizations letter about CHAP peer review, October 11, 2012

American Chemistry Council letter about CHAP and DINP, September 27, 2012

American Chemistry Council letter about CHAP and OMB’s Peer Review guidelines, August 24, 2012

Transmittal Email [PDF] from Eileen Conneely, American Chemistry Council regarding a letter [PDF] from Cal Dooley, CEO, American Chemistry Council, to CPSC Chairman Inez Tenenbaum. August 13, 2012

Transmittal Email [PDF] from Dr. Wolfgang Dekant, University of Wuerzburg, with attachment [PDF], "Comparison of potential endocrine disrupting properties of di-isononyl phthalate (DINP), di-isodecyl phthalate (DIDP), and di-n-butyl phthalate (DNBP)," prepared for the European Council for Plasticizers and Intermediates, June 20, 2012


Letter [PDF] from Eileen Conneely, American Chemistry Council, regarding DIDP and skeletal effects, June 19, 2012


Letter [PDF] from Lorenz Rhomberg, Gradient Corporation, re. Rhomberg LR, Goodman JE, Foster WG, Borgert CJ, Van Der Kraak G. A critique of the European Commission Document, "State of the Art Assessment of Endocrine Disrupters". Crit Rev Toxicol. 2012 May 26. [Epub ahead of print]. DOI: 10.3109/10408444.2012.690367 


E-mail [PDF] from John Hankwitz, March 25, 2012


Transmittal Email from Steve Risotto, American Chemistry Council, September 19, 2011

• Göen et al. (2011) Trends of the internal phthalate exposure of young adults in Germany - Follow-up of a retrospective human biomonitoring study. International Journal of Hygiene and Environmental Health (in press). This article is copyrighted and therefore anyone who wants to obtain a copy can request it from the International Journal of Hygiene and Environmental Health.

Commercial status of other phthalates, Comments to CPSC 1-25-2011, P. Harmon, BASF [PDF]


Miscellaneous phthalates - status of use in N. America, P. Harmon, BASF [PDF]


REACH registered products from ECHA, Steve Risotto, American Chemistry Council [PDF]


REACH: Substances Intended to be Registered as of 30-Nov-2010, Steve Risotto, American Chemistry Council [PDF]


Letter [PDF] from Latham & Watkins - Request to Present New Data to the Chronic Hazard Advisory Panal (CHAP) on Phthalates, August 29, 2011 and CPSC Staff Reply [PDF], September 15, 2011


Letter from Michael A. Kamrin, Ph.D., Michigan State University [PDF], September 28, 2011

• Kamrin, Michael A.(2009) Phthalate Risks, Phthalate Regulation, and Public Health: A Review. Journal of Toxicology and Environmental Health, Part B,12:2,157-174.

Letter [PDF] from Steve Risotto re. Borgert, C.J., et al. The human relevant potency threshold: Reducing uncertainty by human calibration of cumulative risk assessments. Regul. Toxicol. Pharmacol. (2011), doi:10.1016/j.yrtph.2011.10.012


Contractor Technical Reports: Toxicity reviews of 10 phthalates prepared by Versar, Inc. and SRC, Inc. October 2010

• Toxicity review of dimethyl phthalate (DMP)
• Toxicity review of diethyl phthalate (DEP)
• Toxicity review of diisobutyl phthalate (DIBP)
• Toxicity review of diisoheptyl phthalate (DIHP)
• Toxicity review of dicyclohexyl phthalate (DCHP)
• Toxicity review of diisooctyl phthalate (DIOP)
• Toxicity review of di(C9-11) phthalate (Di911P)
• Toxicity review of di(2-propylheptyl) phthalate (DPHP)
• Toxicity review of ditridecyl phthalate (DTDP)
• Toxicity review of diundecyl phthalate (DUP)

Transmittal Emails from Steve Risotto, American Chemistry Council, September 25, 2009, August 28, 2009 and April 21, 2010

• Interspecies Bioassay SOT Poster
• Concentration Database - DEHP 2009 [PDF]
• Concentration Database - Other PEs 2009 [PDF]
• Phthalate Database References 2009 [PDF]
• Phthalate Monoesters 2009 [PDF]
• Aylward LL, Hays SM, Gagné M, Krishnan K. (2009) Derivation of biomonitoring equivalents for di(2-ethylhexyl)phthalate (CAS No. 117-81-7). Regulatory Toxicology and Pharmacology 55: 249-258.
• Aylward LL, Hays SM, Gagné M, Krishnan K. (2009) Derivation of biomonitoring equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP). Regulatory Toxicology and Pharmacology 55:259-267.

Approach to Cumulative Risk, ExxonMobil, PowerPoint Presentation, March 23, 2010 [PDF]

Eastman Chemical Company Cover Letter, March 1, 2010 [PDF]

Diisononyl Phthalate (DINP) Carcinogenicity Hazard Assessment, ExxonMobil Chemical Company, February 16, 2010 [PDF]

Robust Summary for DINCH, January 6, 2010 [PDF]

Robust Summary for DPHP, January 6, 2010 [PDF]

Toxicity Summary for Eastman 168 Plasticizer, January 5, 2010 [PDF]

CPSC Meeting, Non-Phthalate Ester Plasticizers Panel (PowerPoint Presentation), American Chemistry Council, December 15, 2009 [PDF]

Plasticizers and the CPSIA, PowerPoint Presentation, ExxonMobil, July 16, 2009 [PDF]

BASF Meeting with CPSC (PowerPoint Presentation), June 22, 2009 [PDF]

Review of Recent Scientific Data on Di-isononyl Phthalate (DINP) and Risk Characterisation for its use in Toys and Childcare articles, European Council for Plasticisers and Intermediates, Technical Report 2009-0601-DINP, June 2009 [PDF]

Toxicity Summary for Eastman TXIB Formulation Additive, Eastman Chemical Company, November 28, 2007 [PDF]

Chen CY (2004) Biosynthesis of di-(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) from red alga - Bangia atropurpurea. Water Research38: 1014-1018

Namikoshi M, Jujiwara T, Nishikawa T, Ukai K (2006) Natural abundance¹⁴C content of dibutyl phthalate (DBP) from three marine algae. Marine Drugs4: 290-297.

Transmittal Email [PDF] from Steve Risotto, American Chemistry Council regarding Heger NE, Hall SJ, Sandrof MA, McDonnell EV, Hensley JB, McDowell EN, Martin KA, Gaido KW, Johnson KJ, Boekelheide K (2012)Human Fetal Testis Xenografts Are Resistant to Phthalate-Induced Endocrine Disruption. Environmental Health Perspectives. Online April 17, 2012